Effects from Oral Administration of Recombinant Interferon-Alpha on Piglet Daily Care

The administration of interferon has improved the antiviral and immunomodulatory abilities piglets, which is conductive to prevention potential diseases or delay appearance clinical symptoms. This study aimed evaluate effects from recombinant interferon-alpha (IFN-α) on daily care piglets. results were compared a Chinese herbal drug that was shown increase serum levels. In addition, routes oral intramuscular injection evaluated. Forty (40) piglets with equal age weight randomly divided into four groups: control group (group C, without treatment), H (treated compound herbal), K (administered orally IFN-α, 1500 IU per day piglet), J intramuscularly 4×106 piglet). After treatment 15 days, both IFN-α significantly secretion IFN-gamma (IFN-γ) ( P < 0.05 ), pathway faster. expression levels IFN-stimulated genes (MX1 ISG15) enhanced id="M2"> 0.01 independently time IFN-γ level. Different other studies, showed weaker stimulation in indicated interferon-induced response at molecular levels, may be applied for improving autoimmunity